The Ant Bully is a 2006 American animated film written and directed by John A. Davis and based on the 1999 children's book of the same name by John Nickle. Starring the voices of Julia Roberts, Nicolas Cage, Meryl Streep, Paul Giamatti, Regina King, Bruce Campbell and Lily Tomlin, it was produced by Tom Hanks and Gary Goetzman's Playtone, Davis and Keith Alcorn's DNA Productions, and Legendary Pictures in their first animated film, and distributed by Warner Bros. Pictures.

Set in suburban Las Vegas, The Ant Bully follows Lucas Nickle (Zach Tyler Eisen), a 10-year-old destructive boy who is neglected by his family (Cheri Oteri and Larry Miller) and bullied by Steve (Myles Jeffrey) and his friends (Jake T. Austin). He attacks the nearby ant colony out of frustration, but Zoc (Cage), a wizard ant, creates a potion to shrink Lucas. After being shrunk by Zoc, Lucas must join forces with his new friends (Roberts, King, and Campbell) to defeat Stan Beals (Giamatti), an exterminator who threatens their colony upon signing the contract.

Shortly before its release, most of the DNA employees were laid off and the studio was closed (as the result of their second and final film to be made after Jimmy Neutron: Boy Genius). It was also the last film role by Ricardo Montalbán, before his death on January 14, 2009. Released on July 28, 2006, The Ant Bully received mixed reviews from critics, with praise aimed at the vocal performances, animation, and humor, but criticism for its dialogue and script, its lack of faithfulness to the source material and the execution of its premise. It was also a box-office bomb, grossing $55.2 million against its $50 million budget.