The 49th Man is a 1953 American film noir crime film directed by Fred F. Sears and starring John Ireland and Richard Denning. It was released by Columbia Pictures. The Cold War thriller was based on a story by Ivan Tors and the screenplay written by Harry Essex.

The film's title is a cryptic reference to the men in the film hired to smuggle 48 nuclear weapons components into the United States as part of a secret war game and the unexpected 49th man, using the war game as cover, smuggling in a real atomic bomb as part of a plot to destroy an American city.