Garfield: A Tail of Two Kitties (released in some countries as Garfield 2) is a 2006 American comedy film directed by Tim Hill and written by Joel Cohen and Alec Sokolow. It is the sequel to the 2004 film Garfield: The Movie. The film stars Breckin Meyer, Jennifer Love Hewitt, and Bill Murray reprising their respective roles as Jon Arbuckle, Dr. Liz Wilson, and the voice of Garfield. New cast members include Billy Connolly, Ian Abercrombie, Roger Rees, Lucy Davis and Oliver Muirhead in live-action roles and Tim Curry, Bob Hoskins, Rhys Ifans, Vinnie Jones, Joe Pasquale, Richard E. Grant, and Jane Leeves as the voices of the film's new animal characters. In the film, Garfield, Odie, Liz and Jon travel to the United Kingdom, where Prince, another cat that looks exactly like Garfield, is ruling over a castle after the death of his owner. His reign is soon jeopardized by an evil aristocrat, who plans to remodel the castle into condominiums, destroy the estate, and get rid of Prince.

Produced by Davis Entertainment for 20th Century Fox, it was released in the United States on June 16, 2006. Despite being a commercial success, grossing $143 million against its $60 million budget, like its predecessor, the film also received generally negative reviews from critics. A video game of the same name was developed by The Game Factory.