Lost Souls is a 2000 American apocalyptic supernatural horror film directed by Janusz Kamiński, in his directorial debut, and starring Winona Ryder, Ben Chaplin, Elias Koteas, and John Hurt. Its plot focuses on a devout Catholic woman who becomes convinced through the decoding of ciphers that a successful writer has been designated by Satan to become to antichrist.

Completed in 1998 from a screenplay by Pierce Gardner and co-produced by Meg Ryan, Lost Souls was delayed from theatrical release due to the saturation of similarly themed horror films at the nearing of the millennium, such as End of Days and Stigmata (both released in 1999). It was released theatrically in the United States on October 13, 2000. It received largely negative reviews and was a box-office bomb, grossing $31.4 million against a $50-million budget.