Shake, Rattle and Roll 12 is a 2010 Filipino horror anthology film produced by Regal Entertainment and the twelfth installment of the Shake, Rattle & Roll film series. It is directed by Zoren Legaspi, Topel Lee and Jerrold Tarog. The film stars an ensemble cast including Shaina Magdayao, Carla Abellana, Andi Eigenmann, John Lapus, Rayver Cruz, Sid Lucero, Ricky Davao, Jackie Lou Blanco, Rita Avila, Malou Crisologo, Regine Angeles, Martin Escudero, Nash Aguas, Elijah Alejo, Anna Vicente, Kristel Moreno, Niña Jose, John Feir, and Gaby Dela Merced.

The film was distributed by Regal Entertainment and Regal Multimedia. It was an official entry in the 2010 Metro Manila Film Festival.

It is also the last film appearance of actor John Apacible, who died in a shooting incident in Quezon City, Diliman on March 20, 2011, at the age of 38.The thirteenth installment, Shake, Rattle & Roll 13, was released in 2011.