Chandramukhi (transl. Moon-faced girl) is a 2005 Indian horror comedy film written and directed by P. Vasu. It is an official remake of the Kannada film Apthamitra (2004) which is adaptation of Malayalam film Manichitrathazhu (1993). It was filmed simultaneously in Tamil and Telugu. The film stars Rajinikanth, Jyothika (who played the title role) and Prabhu in the principal roles along with an ensemble supporting cast. It revolves around a woman who suffers from dissociative identity disorder that affects a family, and a psychiatrist who intends to solve the case while risking his life.

Chandramukhi was produced by Prabhu and his brother Ramkumar Ganesan through their company Sivaji Productions, and is the company's 50th film. The soundtrack album and background score were composed by Vidyasagar. Cinematography was handled by Sekhar V. Joseph and editing was done by Suresh Urs. Principal photography began on 24 October 2004 and was completed in March 2005. The film was made on a budget of ₹190 millions.

Chandramukhi was released on 14 April 2005 on the eve of the Tamil New Year. The film became a major box office success, with a theatrical run of 890 days at Shanti Theatre. The film won five Tamil Nadu State Film Awards, four Film Fans' Association Awards and two Filmfare Awards. Jyothika and Vadivelu were each awarded a Kalaimamani Award for their work on the film. A sequel Chandramukhi 2 was released in 2023.