Nothing in Common is a 1986 American comedy-drama film directed by Garry Marshall. It stars Tom Hanks and Jackie Gleason in Gleason's final film role; he was suffering from cancer during the production and died less than a year after the film's release.

The film was not considered a big financial success on initial release, though it became more popular as Hanks' fame grew. It is considered by some to be a pivotal role in Hanks' career because it marked his transition from less developed comedic roles to leads in more serious stories, and many critics also praised Gleason's performance.