Orphan: First Kill is a 2022 American psychological horror film directed by William Brent Bell, written by David Coggeshall, based on a story by David Leslie Johnson-McGoldrick and Alex Mace. It is a prequel to the 2009 film Orphan. It stars Isabelle Fuhrman, Julia Stiles, Rossif Sutherland, Hiro Kanagawa, and Matthew Finlan.

With the working title of Esther, the project was announced in February 2020. The official title was revealed in November that same year, with Fuhrman reprising her role as Esther. Filming took place in Winnipeg, Canada, from November to December 2020.

Orphan: First Kill premiered first in other territories starting in the Philippines on July 27, 2022, and was released in the United States on August 19, by Paramount Pictures through the Paramount Players label in select theatres, digital, and streaming via Paramount+. The film has grossed $44 million worldwide and received mixed reviews from critics, who praised the film's twists, practical effects (in regard to de-aging Fuhrman without CGI) and Fuhrman's performance, but criticized its story and inconsistencies.