The Trouble with Angels is a 1966 American comedy film about the adventures of two girls in an all-girls Catholic school run by nuns. The film was the final theatrical feature to be directed by Ida Lupino and stars Hayley Mills (her first post-Disney film role), Rosalind Russell, and June Harding.

The film's cast includes Marge Redmond (who would play a nun in the television series The Flying Nun, which premiered the following year) as math teacher Sister Liguori, Mary Wickes (who reprised her role in the sequel Where Angels Go, Trouble Follows and later played a nun in the film Sister Act and its sequel Sister Act 2: Back in the Habit) as gym teacher Sister Clarissa, and Portia Nelson (who played a nun in The Sound of Music the previous year) as art teacher Sister Elizabeth. Burlesque performer Gypsy Rose Lee appears in a small role. An uncredited Jim Hutton appears briefly as the principal of a competing school.

A sequel, Where Angels Go, Trouble Follows, starring Stella Stevens, was released in 1968, with Russell, Barnes, Mary Wickes and Dolores Sutton all reprising their roles as nuns.