The Powerpuff Girls Movie is a 2002 American animated prequel superhero film based on the Cartoon Network animated television series The Powerpuff Girls. It was co-written and directed by series' creator Craig McCracken (in his feature-length directorial debut), co-written by Charlie Bean, Lauren Faust, Paul Rudish, and Don Shank, and stars the regular television cast of Catherine Cavadini, Tara Strong, E. G. Daily, Roger L. Jackson, Tom Kane, Tom Kenny, Jennifer Hale, and Jennifer Martin. Serving as an origin story of the titular characters, the film follows the newly-created girls as they become ostracized for inadvertently destroying Townsville and assisting in Mojo Jojo's plot for world domination.

The film was released in theaters on July 3, 2002, being the first theatrical adaptation of a Cartoon Network series, as well as the first theatrical film produced by Cartoon Network Studios, while Warner Bros. Pictures handled distribution. The Powerpuff Girls Movie received mixed reviews from critics, who praised its loyalty to the series, but were polarized on the film's violence and comparatively darker tone while also criticizing its pacing. The film was also a box-office failure, earning $16.4 million worldwide on a budget of $11 million, which was primarily blamed on a crowded marketplace. McCracken would later express dissatisfaction in the final product.