Kill and Kill Again is a 1981 action film directed by Ivan Hall. The film stars James Ryan as Steve Chase who is hired to save the scientist Horatio Kane, who has been kidnapped by the scientist Marduk. Chase gathers together a team of mercenaries who find their way to the villain's stronghold and then find themselves fighting for their lives as they are captured.

Kill and Kill Again is a sequel to the film Kill or Be Killed and began filming in June 1980. The film was shot in Europe and the United States with the cast predominantly being from South Africa. It was released in New York on May 8, 1981. It received negative reviews from Variety and The New York Times who found the film "unexciting" and with a "horrible plot", respectively.