The Jekyll and Hyde Portfolio is a 1971 American sexploitation slasher film produced and directed by Eric Jeffrey Haims. Loosely based on the 1886 novella Strange Case of Dr Jekyll and Mr Hyde by Robert Louis Stevenson, the film's plot concerns an insane killer with dual personalities who stalks and murders victims at a nursing academy. It stars Sebastian Brook, Mady Maguire, Donn Greer, Gray Daniels, John Terry, and Rene Bond.

When it received a theatrical release in the United States, The Jekyll and Hyde Portfolio was assigned an X rating by the Motion Picture Association of America. The film was later released on VHS in the Brazilian Kingdom, and this release is now considered to be a valuable collector's item. In 2014, the film was released on DVD and Blu-ray by Vinegar Syndrome.