Dr. Pimple Popper is an American reality television series airing on TLC. The series, starring dermatologist and Internet celebrity Dr. Sandra Lee, follows her as she treats patients with unusual cases of facial and skin disorders at her clinic Skin Physicians & Surgeons in the Inland Empire city of Upland, California. The show started with an hour-long special on January 3, 2018 before the first season aired on July 11, 2018.Initially airing at 10:00 p.m. Eastern Time on Wednesdays, Dr. Pimple Popper became the top-rated cable program in its time slot among women between ages 25–54. On August 14, the day before the final episode for Season 1 aired, TLC announced it had renewed the series for a second season, with new episodes set to air in January 2019. Another hour-long special was aired on December 13, 2018, before the second season began on January 3, 2019 with its episodes moved to 9 p.m. Eastern Time on Thursdays. Beginning part-way through the fifth season, new episodes became available on the Discovery+ streaming service, before returning to TLC for the sixth season. A spin-off series titled Dr. Pimple Popper: Before the Pop premiered on September 3, 2020.

The ninth season premiered on April 5, 2023.