Cleopatra in Space is an American animated television series produced by DreamWorks Animation and animated by Titmouse, Inc., based on the graphic novel series of the same name by Mike Maihack. The showrunners for the series are Doug Langdale and Fitzy Fitzmaurice.

In the United States, the first five episodes were released on NBCUniversal's streaming service Peacock for Xfinity customers on April 15, 2020, making this the first DreamWorks Animation series to be released on a streaming device other than Netflix or Prime Video. On July 15, 2020, the first season was officially released when the service launched nationwide. Prior to its release in the United States, the series was first broadcast in Southeast Asia on DreamWorks Channel beginning on November 25, 2019. The show is geared toward those between ages 6 and 11. Langdale, in an interview, said that he is attempting to make sure the show is "accessible to a younger audience," even as he doesn't give much thought to what age demographic the show is aiming towards.On July 15, the show premiered on Peacock, with episodes 1–5 and 7–13 of the first season made available to viewers who subscribed to "Peacock Premium", and a more limited selection for those who chose a free plan. It was one of the three animated Peacock Originals streaming on the platform, with the other two being season 13 of Curious George and season 2 of Where's Waldo?. The show can only be watched using the streaming service's premium plan. On November 19, 2020, Season 2 premiered on Peacock. On January 14, 2021, Season 3 was released on Peacock. On July 14, 2021, all three seasons were added to Hulu.