The Adventures of Shirley Holmes is a children's mystery television series that aired on YTV from May 7, 1997, to May 7, 2000. The show was created by Ellis Iddon and Phil Meagher (of Winklemania Productions, UK) who had produced a successful series of books with HarperCollins, teaming up with Credo, Forefront, Winchester and Winklemania to develop the TV series. Filmed in Winnipeg, Manitoba, the series follows the life of Shirley Holmes, the great-great-niece of Sherlock Holmes who, with the help of ex-gang member Bo Sawchuk, tackles a variety of mysteries in and around the fictional city of Redington, Manitoba. On some occasions, she found herself matching wits with nemesis Molly Hardy (whose name is a word play on Sherlock Holmes' archenemy Professor Moriarty).

The show has been broadcast in over 80 countries and has been dubbed in French, Spanish, Italian, Portuguese, German, Norwegian, Russian, Serbian, Polish and Turkish.

Her performance in the show led to actress Meredith Henderson being nominated for a Gemini Award in 1998 and winning one in 1999. The show itself was twice nominated for a Gemini Award in the category "Best Children's or Youth Program or Series" in 1998 and eventually won it in 1999. In the spring of 1998 Susin Nielsen won a Gemini Award in the category "Best Writing in a Children's or Youth Program" for her screenplay of the episode "The Case of the Burning Building". In the same year, Elizabeth Stewart won a WGC Award from the Writers Guild of Canada for her writing of the episode "The Case of the Maestro's Ghost".Credo spokesperson and producer Kim Todd named a growth spurt in the cast as one of the key reasons for cancelling the show. The aging of the actors would have meant a distinct change in tone and content had the show continued.