The Big Sick is a 2017 American romantic comedy-drama film directed by Michael Showalter and written by Emily V. Gordon and Kumail Nanjiani. It stars Nanjiani, Zoe Kazan, Holly Hunter, Ray Romano, Adeel Akhtar, and Anupam Kher. Gordon and Nanjiani wrote the film based on their relationship; it follows an interracial couple who must deal with cultural differences after Emily (Kazan) becomes ill.

The film had its world premiere at the Sundance Film Festival on January 20, 2017. It began a limited theatrical release on June 23, 2017, by Amazon Studios and Lionsgate, before going wide on July 14, 2017. One of the most acclaimed films of 2017, it was chosen by American Film Institute as one of the top 10 films of the year and was nominated for the Academy Award for Best Original Screenplay. With a budget of $5 million, it grossed $56 million worldwide, becoming one of the highest-grossing independent films of 2017.