Of Human Bondage is a 1946 American drama film directed by Edmund Goulding and starring Paul Henreid, Eleanor Parker and Alexis Smith. The second screen adaptation of W. Somerset Maugham's 1915 novel, this Warner Bros. sanitized version was written by Catherine Turney. The central characters are Philip Carey, a clubfooted medical student, and Mildred Rogers, a low-class waitress with whom he becomes obsessed.

This is the second film version of Somerset Maugham's classic novel. The first was the 1934 film adaptation, starring Leslie Howard and Bette Davis, and the third was the 1964 film adaptation, starring Laurence Harvey and Kim Novak.