NXT TakeOver: San Antonio was the 13th NXT TakeOver professional wrestling livestreaming event produced by WWE. It was held exclusively for wrestlers from the promotion's NXT brand division. The event aired exclusively on the WWE Network and took place on January 28, 2017, at the Freeman Coliseum in San Antonio, Texas. It was held as part of that year's Royal Rumble weekend, thus being the first NXT TakeOver to be held in January.

Five matches were contested at the event. In the main event, Bobby Roode defeated Shinsuke Nakamura to win the NXT Championship. In other prominent matches, The Authors of Pain (Akam and Rezar) defeated DIY (Johnny Gargano and Tommaso Ciampa) to win the NXT Tag Team Championship, and Asuka defeated Billie Kay, Peyton Royce, and Nikki Cross in a fatal four-way match to retain the NXT Women's Championship.