Mike Tyson Mysteries is an American adult animated television series, and is the first collaboration between Warner Bros. Animation and Williams Street. It premiered on October 27, 2014 on Cartoon Network's nighttime programming block Adult Swim. The series features Mike Tyson (who co-created the series along with Hugh Davidson and Lee Stimmel) solving mysteries, in the style of I Am the Greatest: The Adventures of Muhammad Ali, Scooby-Doo, Jonny Quest, and Mister T. On December 10, 2014, Adult Swim renewed the series for a second season, which premiered on November 1, 2015. A third season premiered on May 14, 2017, and the fourth and final season premiered on June 30, 2019.

During a May 2020 interview, writer Larry Dorf revealed the show had not been renewed and the fourth season would be its last. Adult Swim has aired reruns as of 2024.