In a rural village, there lives a man named Zoroku, with his sister, Haruko. All is well until one day, Zoroku becomes infected with a bizarre disease that blisters his skin and deforms his body. Fearing the reactions of the townspeople, his parents lock him in the house. Unfortunately, the village chief sees him, and soon, Zoroku and Haruko are mistreated by everyone in the village. Unable to watch Haruko suffer any longer, the parents decide to end Zoroku's misery themselves. Haruko tries to save her brother, and they leave home, but what comes afterward?

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