Little Iodine is a 1946 American comedy film directed by Reginald Le Borg and written by Richard H. Landau. The film is based on the comic strip Little Iodine by Jimmy Hatlo. The film stars Jo Ann Marlowe, Marc Cramer, Eve Whitney, Irene Ryan, and Hobart Cavanaugh. The film was released on October 20, 1946, by United Artists. All prints of the film were destroyed after 10 years, effectively making it a lost film.