Jigoku Sensei Nūbē (地獄先生ぬ〜べ〜, lit. "Hell Teacher Nūbē") is a Japanese manga series written by Shō Makura and illustrated by Takeshi Okano. It was serialized in Shueisha's magazine Weekly Shōnen Jump from September 1993 to May 1999. The manga ran for 276 chapters and was compiled into 31 tankōbon volumes. The series follows Meisuke Nueno, aka Nūbē, the homeroom teacher for Class 5–3 at Dōmori Elementary. More than a teacher, however, he is a skilled exorcist, protecting the town of Dōmori from supernatural threats with strength borrowed from a powerful demon sealed in his left hand—a technique he calls the Demon's Hand. The manga was adapted into a 49-episode anime series by Toei Animation, and aired from April 1996 to August 1997 on TV Asahi. The anime resulted in three movies and three OVA episodes.

A spin-off story for Izuna Hazuki the itako-girl, Reibaishi Izuna: The Spiritual Medium, was serialized in Oh Super Jump and later in Super Jump from July 2007 to October 2011. A sequel to the spin-off, titled Reibaishi Izuna: Ascension started in November 2011 and finished in June 2016. In May 2014, a Jigoku Sensei Nūbē direct sequel has started with the premise of ten years having passed, with Kyoko becoming a teacher at the Dōmori Elementary and Nūbē returning to the school from Kyushu. The manga finished in December 2018. A sequel titled Jigoku Sensei Nūbē S started in Saikyō Jump in August 2018.

As of December 2014, the Jigoku Sensei Nūbē manga had 24 million copies in circulation.