The Completely Mental Misadventures of Ed Grimley is an American animated television series produced by Hanna-Barbera Productions and featuring Martin Short's fictional character Ed Grimley (with Short reprising his role as Grimley). The show aired on NBC from September 10 to December 3, 1988 for a single season of 13 episodes. The show is the only Saturday morning animated adaptation of both an SCTV character and a Saturday Night Live character, and the first Saturday morning cartoon featuring an SCTV cast member (later joined by Camp Candy, featuring John Candy, and Rick Moranis's Gravedale High).

Guest stars on the show included Christopher Guest and SCTV alumni Eugene Levy and Dave Thomas. The show also featured the voices of René Auberjonois, Kenneth Mars, and Arte Johnson. Though the show was not renewed for a second season, The Completely Mental Misadventures of Ed Grimley was later seen in reruns in 1996 on Cartoon Network's unnamed pre-Adult Swim-era late-night programming block, which consisted of such shows as Space Ghost Coast to Coast and reruns of classic Looney Tunes shorts and Hanna-Barbera programming, before it was rerun again on Boomerang. Hanna-Barbera sponsored an Ed Grimley look-alike contest midway through the first season, which was won by 10-year-old Matt Mitchell from Des Moines, Iowa.