Los misterios de Laura (transl. The Mysteries of Laura) is a prime-time Spanish police procedural comedy-drama television series that was broadcast on La 1 of Televisión Española from 2009 to 2014, followed by three television movies broadcast in 2022 and 2023. It stars María Pujalte as Laura Lebrel, a police detective with a disorganized personal and professional life, and a casual and pleasant personality, but with a great nose and intuition for solving intriguing cases.

The series, that was initially going to be named Madres y detectives (transl. Mothers & Detectives), premiered on 27 July 2009 with huge success, surpassing the rival of the night CSI: Crime Scene Investigation. It mixes elements of TV series like Murder, She Wrote or Columbo, and at the same time it recovers elements of the mystery novels by Agatha Christie.

The series has been adapted in Italy as I misteri di Laura starring Carlotta Natoli, the Netherlands as Rechercheur Ria starring Ellen Pieters and Russia as Mama-detektiv starring Inga Strelkova-Oboldina. On 8 May 2014 American network NBC announced an American adaptation, titled The Mysteries of Laura and starring Debra Messing.