Muppets from Space is a 1999 American science fiction comedy film directed by Tim Hill (in his feature directorial debut), written by Jerry Juhl, Joseph Mazzarino, and Ken Kaufman, and produced by Brian Henson and Martin G. Baker, with Stephanie Allain and Kristine Belson serving as executive producers. The sixth theatrical film featuring the Muppets, it stars Muppet performers Dave Goelz, Steve Whitmire, Jerry Nelson, Bill Barretta, and Frank Oz, as well as Jeffrey Tambor, F. Murray Abraham, David Arquette, Josh Charles, Hollywood Hogan, Ray Liotta, and Andie MacDowell. In the film, Gonzo attempts to discover his origins. After he and Rizzo the Rat are captured by government officials during his search, Kermit the Frog and the rest of the Muppets set out to rescue them.

The first Muppet film to not be a musical, Muppets from Space was shot in Wilmington, North Carolina in 1998. Jamshied Sharifi composed the film's score, with additional music composed by Rupert Gregson-Williams.

Produced by Columbia Pictures in association with Jim Henson Pictures, Muppets from Space was released in the United States on July 14, 1999, by Columbia's parent company Sony Pictures Releasing. It grossed $22.3 million against a budget of $24 million, making it a box office bomb, and received mixed reviews from critics; many considered it the weakest theatrical Muppet movie. It is the last Muppet film to have the involvement of Oz and Juhl and the last theatrically-released Muppet film to be produced by The Jim Henson Company before the franchise was acquired by The Walt Disney Company in 2004.