The 40-Year-Old Virgin is a 2005 American romantic comedy film directed by Judd Apatow (in his feature directorial debut), who produced the film with Clayton Townsend and Shauna Robertson. It features Steve Carell as the titular 40-year-old virgin Andy, an employee at an electronics store. Paul Rudd, Romany Malco, and Seth Rogen play co-workers who resolve to help him lose his virginity, and Catherine Keener stars as Andy's love interest, Trish.

Watching Carell's performance in Anchorman: The Legend of Ron Burgundy (2004) inspired Apatow to cast him in the lead role for the film, and they wrote The 40-Year-Old Virgin together. It was based on a sketch Carell created with The Second City where a man aged 40 hides a secret. Filming took place in Los Angeles and San Fernando Valley, California, from January to April 2005.

The film was released theatrically in the United States on August 19, 2005, through Universal Pictures, and grossed over $177 million worldwide on a $26 million budget. Reviews were generally favorable, praising Carell's performance and the film's well-meaning yet bawdy humor, which was a point of contention by some conservative commentators as well. He won accolades from the Golden Schmoes Awards and MTV Movie & TV Awards for this role while Keener received awards from the Boston Society of Film Critics and Los Angeles Film Critics Association. The 40-Year-Old Virgin was named by the American Film Institute one of 2005's Top 10 Films.