The Prisoner of Shark Island is a 1936 American drama film loosely based on the life of Maryland physician Samuel Mudd, who treated the injured presidential assassin John Wilkes Booth and later spent time in prison after his controversial conviction for being one of Booth's accomplices. The film was produced by Darryl F. Zanuck, was directed by John Ford and starred Warner Baxter and Gloria Stuart.

Twentieth Century Pictures, before it merged with Fox, purchased the rights to the book The Life of Dr. Mudd by Nettie Mudd Monroe, the doctor's daughter. The film's credits, however, make no reference to Monroe or her book. Modern sources state that Darryl F. Zanuck, Twentieth Century's vice-president in charge of production, got the idea to make the film after he read an article in Time magazine about the prison camp for political prisoners on the Dry Tortugas island.