Coyote vs. Acme is an upcoming American live-action animated legal comedy film directed by Dave Green with a screenplay by Samy Burch from a story by Burch, James Gunn, and Jeremy Slater. The film is based on the 1990 The New Yorker magazine article "Coyote v. Acme" by Ian Frazier, which itself is based on the cartoon character Wile E. Coyote and the Acme Corporation from the Looney Tunes and Merrie Melodies series of cartoons. The film's cast includes John Cena, Will Forte, Lana Condor, P. J. Byrne, Tone Bell, Martha Kelly, and the voice of Eric Bauza.

Development began in August 2018 with Chris McKay as producer and Jon and Josh Silberman writing the screenplay. Green was hired to direct in December 2019, and Burch, Slater, and Gunn joined the following year. Cena, Forte and Condor were cast in early 2022. Live-action filming took place in New Mexico from March to May 2022.

Warner Bros. Discovery initially shelved Coyote vs. Acme in November 2023 to obtain a tax write-off, but they later reversed their decision and allowed the filmmakers to seek other distributors following public backlash. After several unsuccessful negotiations with various distributors, Ketchup Entertainment acquired the rights in March 2025 after previously doing so with Warner Bros. Animation's The Day the Earth Blew Up: A Looney Tunes Movie. The film is set to be released in 2026.