Coyote vs. Acme is an unreleased American live-action/animated legal comedy film directed by Dave Green and written by Samy Burch from a story by Burch, James Gunn and Jeremy Slater. The film is based on the 1990 The New Yorker magazine article "Coyote v. Acme" by Ian Frazier, which itself is based on the cartoon character Wile E. Coyote and the Acme Corporation from the Looney Tunes and Merrie Melodies series of cartoons. The film's cast includes John Cena, Will Forte, Lana Condor, P.J. Byrne, Tone Bell, Martha Kelly, and the voice of Eric Bauza.

Development began in August 2018 with Chris McKay as producer and Jon and Josh Silberman writing the screenplay. Green was hired to direct in December 2019, and Burch, Slater, and Gunn joined the following year. Cena, Forte and Condor were cast in early 2022. Live-action filming took place in New Mexico from March to May 2022.

Warner Bros. Discovery shelved Coyote vs. Acme in November 2023 to obtain a $30 million tax write-off, making it the third film shelved by Warner Bros. after Batgirl and Scoob! Holiday Haunt. Following public backlash, Warner Bros. allowed the filmmakers to shop the film to other distributors. In February 2024, following unsuccessful negotiations with potential buyers, Warner Bros. Discovery again considered shelving the film and claiming a tax loss, although in March 2024 it was revealed by Burch that conversations within Warner Bros. Discovery were still ongoing as to whether or not the film would be released, and as of April 2024 the film remains "available for acquisition" according to a Warner Bros. spokesperson.