Dr. Pyckle and Mr. Pryde (or Dr. Pyckle and Mr. Pride) is a 1925 American silent, black-and-white comedy horror film, directed by Scott Pembroke and Joe Rock (also the producer).

The film itself is both a spoof of the previous Dr. Jekyll and Mr. Hyde films (e.g. Dr. Jekyll and Mr. Hyde (1912) and Dr. Jekyll and Mr. Hyde (1920), both adaptations of and the 1886 novella by Robert Louis Stevenson Strange Case of Dr Jekyll and Mr Hyde). The film stars Stan Laurel as the title character.