Mystery House is a 1938 American mystery crime film directed by Noel M. Smith and starring Dick Purcell and Ann Sheridan as nurse Sarah Keate, and is based on the 1930 novel The Mystery of Hunting's End by Mignon G. Eberhart. Sheridan also played the same character in The Patient in Room 18, released in January 1938, while Aline MacMahon played her in While the Patient Slept in 1935.

In the film, a banker announces that he has discovered an embezzlement scheme. He is murdered shortly after his announcement. His daughter assigns a private detective to investigate the case. But a series of murders begins, with the suspects being targeted.