Roadblock: End of the Line was the second Roadblock professional wrestling livestreaming event produced by WWE. It was held exclusively for wrestlers from the promotion's Raw brand division. While the first Roadblock was streamed exclusively on the WWE Network, this second event also aired via traditional pay-per-view (PPV) outlets. It took place on December 18, 2016, at the PPG Paints Arena in Pittsburgh, Pennsylvania. The name of the event was a reference to it being WWE's final PPV of 2016. This was the final Roadblock until 2022 when WWE revived the event as a television special for the NXT brand.

Seven matches were contested at the event, including one on the Kickoff pre-show. In the main event, Kevin Owens retained the WWE Universal Championship against United States Champion Roman Reigns by disqualification when Chris Jericho attacked Owens. In the opening bout, the team of Cesaro and Sheamus defeated The New Day (Big E and Kofi Kingston) for the Raw Tag Team Championship, ending New Day's reign 483 days, the longest tag team championship reign on WWE's main roster until November 2022. In other prominent matches, Rich Swann retained the WWE Cruiserweight Championship against The Brian Kendrick and T. J. Perkins in a triple threat match, Seth Rollins defeated Chris Jericho, and Charlotte Flair defeated Sasha Banks in overtime of a 30-minute Iron Man match to win her record fourth Raw Women's Championship.