Chelsea Girls is a 1966 American experimental underground film directed by Andy Warhol and Paul Morrissey. The film was Warhol's first major commercial success after a long line of avant-garde art films (both feature-length and short). It was shot at the Hotel Chelsea and other locations in New York City, and follows the lives of several of the young women living there, and stars many of Warhol's superstars. The film is presented in a split screen, accompanied by alternating soundtracks attached to each scene and an alternation between black-and-white and color photography. The original cut runs at just over three hours long.

In 2024, the film was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant."