Patient Zero is a 2018 science fiction horror film directed by Stefan Ruzowitzky and written by Mike Le. The film stars Matt Smith, Natalie Dormer, John Bradley, Stanley Tucci, Agyness Deyn, and Clive Standen. The plot involves a group of survivors who set out to find an antidote for a highly contagious virus that turns the infected into a ravenous but highly intelligent new species.

After a bidding war between several studios over a script penned by Le, Screen Gems eventually won the rights. Ruzowitzky signed on to direct in May 2014. Casting began in September 2014 and lasted until March 2015. Principal photography began on 3 March 2015 in London, before ending on 18 April.

Originally set to be released in September 2016, Patient Zero was pushed back to February 2017 and was removed from the Screen Gems release schedule. The film was finally released through video-on-demand on 14 August 2018, with a limited theatrical release on 14 September by Vertical Entertainment.