Scream and Scream Again is a 1970 British science-fiction horror film directed by Gordon Hessler for Amicus Productions, and starring Vincent Price, Christopher Lee, Alfred Marks, Michael Gothard, and Peter Cushing. The screenplay was by Christopher Wicking, based on the 1967 novel The Disorientated Man, attributed to "Peter Saxon", a house pseudonym used by various authors in the 1960s and 1970s.

The film marks the second teaming, after The Oblong Box (1969), of actors Price and Lee with director Hessler. Price and Lee only share a brief scene in the film's climax. Cushing, in his brief scene, shares no screen time with either Price or Lee.

Overlooked during its initial release, the film has since become a minor cult classic, with the Overlook Film Guide acknowledging it as "one of the best science-fiction films made in Britain."