Reign Over Me is a 2007 American buddy drama film written and directed by Mike Binder, produced by his brother Jack Binder, and starring Adam Sandler, Don Cheadle, Jada Pinkett Smith, Liv Tyler, Donald Sutherland, Saffron Burrows, and Mike Binder himself. The film follows the story of former college roommates and old friends Alan and Charlie, the latter of whom is struggling with depression after the death of his wife and daughters in the September 11 attacks. This was also Melinda Dillon's final film acting role before retiring from acting later that same year and her death in 2023.

Distributed by Columbia Pictures, the film was theatrically released on March 23, 2007, and on DVD and Blu-ray on October 9, 2007. It is the first of two films produced by Madison 23, a drama subsidiary of Sandler's Happy Madison Productions.