Dominic and the Ladies' Purse is a 2025 Indian Malayalam-language mystery comedy thriller film directed by Gautham Vasudev Menon, in his Malayalam debut, and produced by Mammootty Kampany. The film stars Mammootty in the titular role, alongside Gokul Suresh, Sushmitha Bhat, Viji Venkatesh, Siddique, Vineeth and Vijay Babu. The film revolves around Dominic, a sharp but disgraced ex-cop, nice guy, who knows all the right moves and is now a detective, takes on a simple job to find the owner of a purse.

The film was officially announced in July 2024 under the tentative title Production No: 6, as it is the sixth production venture of Mammootty Kampany, and the official title was announced that September. Principal photography commenced the same month in Kochi. The film has music composed by Darbuka Siva, cinematography handled by Vishnu Dev and editing by Lewellyn Anthony.

The film was released theatrically on 23 January 2025 and received mixed reviews from critics.