Duke of Chicago is a 1949 American sports drama film directed by George Blair and starring Tom Brown, Audrey Long and DeForest Kelley. Produced and distributed by Republic Pictures the film portrays a retired boxer, Jimmy Brody (Brown), who leaves his boxing career for his fiancée but is lured back into a one-off fight against a current champion due to financial difficulties.

Based on the 1933 novel The Duke Comes Back by Lucian Cary, Duke of Chicago was one of several films made on the back of the critical and commercial success of boxing pictures Body and Soul and Champion. However, the film was largely panned by critics, described as "slow-paced and seemingly a lot longer than its fifty-nine minutes."