The 2016 Clash of Champions was a professional wrestling event produced by WWE. It was the inaugural Clash of Champions and took place on September 25, 2016, at the Bankers Life Fieldhouse in Indianapolis, Indiana. The event aired via pay-per-view (PPV) and livestreaming and exclusively featured wrestlers from the promotion's Raw brand division. Clash of Champions replaced WWE's previously annual event, Night of Champions, and it was the first Raw-branded event following the reintroduction of the brand split in July 2016. As per the theme of the event, all championships exclusive to Raw at the time were defended.

Eight matches were contested at the event, including one on the Kickoff pre-show. In the main event, Kevin Owens defeated Seth Rollins to retain the WWE Universal Championship. Of the five Raw-exclusive championships, only the United States Championship changed hands, with Roman Reigns defeating defending champion, Rusev.