The Giant Spider Invasion is a 1975 American independent science fiction action horror film produced, composed and directed by Bill Rebane, and follows giant spiders that terrorize the town of Merrill, Wisconsin and its surrounding area. The film was theatrically released in 1975 by Group 1 Films and enjoyed a considerable run to become one of the 50 top-grossing films of that year.

After a three-time ABC network run, The Giant Spider Invasion achieved further exposure many years later, when it was featured in a 1997 episode of Mystery Science Theater 3000.