The title is a portmanteau on kudomono (fruit) and nou (brains). The anime consists of three two-minutes skits, with basically the same structure. Orange and Pineapple are in Hong Kong, Ancient Egypt, Outer Space. Orange is trying to accomplish something - watching a drug deal go down, taking a break from work, trying to defuse a bomb outside a space station - while Pineapple pesters him with pointless and increasingly obscure questions.

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