Lie with Me is a 2005 Canadian erotic drama film directed by Clement Virgo, based on the 2001 novel of the same name by Tamara Faith Berger. The film stars Lauren Lee Smith and Eric Balfour. Its plot concerns an outgoing, sexually aggressive young woman who meets and begins a torrid affair with an equally aggressive young man, which brings a strain on their personal lives. The film contains graphic, unsimulated sexual content.

The film was set and shot in Toronto, primarily The Annex. It premiered at the 2005 Toronto International Film Festival.

Included in the soundtrack is music by Broken Social Scene and Annelise Noronha.