Frankie and Johnny is a 1991 American romantic comedy-drama film directed by Garry Marshall and starring Al Pacino and Michelle Pfeiffer (in their first film together since Scarface). Héctor Elizondo, Nathan Lane and Kate Nelligan appear in supporting roles. The original score is composed by Marvin Hamlisch.

The screenplay for Frankie and Johnny is adapted by Terrence McNally from his own off-Broadway play Frankie and Johnny in the Clair de Lune, which featured F. Murray Abraham and Kathy Bates. The most notable alteration in the film is the addition of several supporting characters and various locations; in the original play, only the two eponymous characters appear onstage, and the entire drama takes place in one apartment.

The title is a reference to the traditional American popular song "Frankie and Johnny", first published in 1904, which tells the story of a woman who finds her man making love to another woman and shoots him dead. The film received generally favorable reviews and grossed $67 million with a $29 million budget.