Battling with Buffalo Bill is a 1931 American pre-Code Western serial film directed by Ray Taylor and starring Tom Tyler, Lucile Browne, William Desmond, Rex Bell, and Francis Ford.

Based on the book The Great West That Was by William F. "Buffalo Bill" Cody, the film is about a cowboy named Buffalo Bill who goes up against a shady gambler who is attempting to scare off the townspeople so he can gain possession of a gold strike. When a nearby Indian tribe is provoked into attacking the town, the cavalry rides in to the rescue. Cody's book was also used as the inspiration for the studio's highly successful 1930 serial The Indians Are Coming.

Battling with Buffalo Bill was Universal Pictures's 78th serial, the 10th with sound and 4th with full sound, of the studio's total of 137 serials.