Man's Best Friend is a 1993 American science fiction horror film, directed and written by John Lafia. It stars Ally Sheedy, Lance Henriksen, Robert Costanzo, Frederic Lehne, John Cassini, and J. D. Daniels.

It was released by New Line Cinema on November 19, 1993. The film was a modest success at the box office, grossing $12.9 million behind a $6 million budget.

In the film, a television personality frees a Tibetan Mastiff from a genetic research facility, and proceeds to adopt him as a pet. She fails to realize that her dog is a product of genetic engineering, with enhanced strength, speed, and senses. She also fails to realize that her dog has rage-fueled outbursts of violence.