Little Annie Rooney is a 1925 American silent comedy-drama film starring Mary Pickford and directed by William Beaudine. Pickford, one of the most successful actresses of the silent era, was best known throughout her career for her iconic portrayals of penniless young girls. After generating only modest box office revenue playing adults in her previous two films, Pickford wrote and produced Little Annie Rooney to cater to silent film audiences. Though she was 33 years old, Pickford played the title role, an Irish girl living in the slums of New York City.

The film was a critical and commercial success, becoming one of the highest-grossing films of 1925. Restored by the Academy of Motion Picture Arts and Sciences in 2014, Little Annie Rooney is remembered today for Pickford's performance and the high quality associated with its production.