Killer Klowns from Outer Space is a 1988 American science fiction comedy horror film produced by the Chiodo Brothers, who also created the practical effects and makeup, with Stephen directing from a script he co-wrote with Charles; it is the only film written or directed by any of the Chiodos. The film features an ensemble cast starring Grant Cramer, Suzanne Snyder, John Allen Nelson and John Vernon. It concerns evil extraterrestrials that resemble clowns arriving on Earth and invading a small town in order to capture, kill and harvest the human inhabitants for sustenance.

Killer Klowns from Outer Space was filmed in Watsonville, California and at the Santa Cruz Beach Boardwalk. The film utilizes practical effects, including creature suits. The score was composed by John Massari. The film received generally positive reviews and has been considered a cult classic.

Sequels have been in development hell since the original film's release. Stephen Chiodo stated in 2016 that he hopes to produce three additional films, or possibly a television series. In 2018, NBCUniversal's Syfy announced that it was in talks to license the rights to make one or more sequels.