Murder in Harlem (also released as Lem Hawkins Confession and Brand of Cain) is a 1935 American race film written, produced and directed by Oscar Micheaux, who also appears in the film. He remade his 1921 silent film The Gunsaulus Mystery.

Basing the works on the 1913 trial of Leo Frank for the murder of Mary Phagan, Micheaux used the detective genre to introduce different voices and conflicting accounts by his characters. In July 2021, the film was shown in the Cannes Classics section at the 2021 Cannes Film Festival.