Hairspray is a 1988 American comedy film written and directed by John Waters, starring Sonny Bono, Ruth Brown, Divine, Debbie Harry, Ricki Lake in her film debut, and Jerry Stiller, with special appearances by Ric Ocasek in his final film and Pia Zadora. Hairspray was a dramatic departure from Waters's earlier works, with a much broader intended audience. Hairspray's PG is the least restrictive rating a Waters film has received; most of his previous films were rated X by the MPAA. Set in 1962 Baltimore, Maryland, the film revolves around self-proclaimed "pleasantly plump" teenager Tracy Turnblad as she pursues stardom as a dancer on a local TV show and rallies against racial segregation.

Hairspray was a moderate success upon its initial theatrical release, earning $8 million. However, it managed to attract a larger audience on home video in the early 1990s, and it became a cult film. The film received critical acclaim and ranks at No. 444 on Empire magazine's 2008 list of the 500 greatest films of all time.

This is Divine's final film released during his lifetime as he died three weeks after its release.

In 2002, the film was adapted into a Broadway musical of the same name, which won eight Tony Awards, including Best Musical in 2003. A second film version of Hairspray, an adaptation of the stage musical, was also released by New Line Cinema in 2007, which included many changes of scripted items from the original.

In 2022, the film was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant".