Murder in the Big House is a black-and-white American crime drama, released by Warner Bros in April 1942. Structured as an hour-long second feature, it is directed by the prolific specialist in low-budget action productions, B. Reeves Eason, and stars Van Johnson, who is top-billed above the title, in his first credited film role which represents the entire output of his six-month contract with the studio.

The female lead, Faye Emerson, billed alongside Johnson above the title, played starring and co-starring parts in a small number of B pictures during 1940s and achieved TV stardom at the end of the decade and in the 1950s as a glamorous interviewer and personality during the medium's formative years.

Following Johnson's rise to become the 1945 top box-office attraction as a leading man and Emerson's marriage to the president's son, Elliott Roosevelt, the film was re-released to theaters in late 1945 and early 1946 under the title Born for Trouble.