Klondike Kate is a 1943 American Western film directed by William Castle and starring Ann Savage and Tom Neal. Set in Alaska during the Klondike Gold Rush of the 1890s, it is loosely based on the story of a real figure known as Klondike Kate. She personally selected Savage, a contract starlet at Columbia Pictures, to play her. It was the first time Savage appeared in a lead role.

The film's sets were designed by the art director Lionel Banks. Although the film was a B Picture, it had a higher budget than many such productions and employed numerous extras.